Catheter and Seal Assembly

ABSTRACT

A laboratory specimen sealed within a chamber on an animal holder may be injected or otherwise administered material such as drugs and radioactive imagining materials from the ambient, or outside the chamber, through a sealed catheter assembly. The animal holder can be mounted on imaging machines such as MRI, X-ray, PET, CT and like imaging machines. Biologically contaminated animals are isolated within the chamber from the ambient, yet may be injected from outside the chamber thereby protecting lab technicians from contamination and isolating the animal from additional contamination from an ambient environment, such as an imaging laboratory.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit and priority of provisional patentapplication No. 61/196,371 filed Oct. 17, 2008, and which isincorporated herein by reference in its entirety.

BACKGROUND

A need exists for a catheter which can he used to inject laboratoryanimals isolated within imaging chambers constructed for use in imagingmachines such as MRI, X-ray, PET, CT and the like. In some studies, itis necessary to isolate a laboratory specimen, such as a mouse or rat,within a hermetically-sealed container during imaging procedures. Suchtest specimens may be biologically contaminated and should not beexposed to ambient.

During such studies, it is common to inject the specimen in its tailvein with various materials, including radioactive materials, whichenhance the quality of images of the specimen produced by an imagingmachine. After imaging is complete, it is generally desirable to discardthe catheter as it may be contaminated with pathogens, injectates andthe like.

BRIEF DESCRIPTION OF THE DRAWINGS

In the drawings:

FIG. 1 is a perspective view of an animal holding system in a partiallyopen position showing the location of a catheter and seal assemblythereon constructed in accordance with this disclosure;

FIG. 2 is a partial view in axial section of the animal holding systemof FIG. 1 in a hermetically closed position showing the arrangement of acatheter and seal assembly extending from the ambient surroundings intoa hermitically sealed animal holding chamber;

FIG. 3 is an enlarged view of region 3 of FIG. 2;

FIG. 4 is a perspective view of a catheter and seal assembly such asshown in FIG. 1;

FIG. 5 is an enlarged view of region 5 of FIG. 4; and

FIG. 6 is a perspective end view of the seal of FIG. 5.

In the various view of the drawings like numerals designate like orsimilar parts.

DESCRIPTION OF A REPRESENTATIVE EMBODIMENT

As seen in FIG. 1, a modular specimen holder or animal holding system 12is constructed to be removably and selectively mountable to apositioning receiver assembly which is adapted for mounting on orpositioned within an imaging machine. The animal holding system 12includes a specimen alignment bed 14 having a specimen retentionassembly 16 for holding a specimen's head in place during imaging.

An interconnection panel 18 includes electrical and fluid ports andconnectors for monitoring, treating and conditioning a specimen duringimaging. Sensor leads, warming air and anesthesia gas can be channeledthrough the interconnection panel 18. A specimen, such as a mouse orrat, can be hermetically enclosed while on the alignment bed 14 with acylindrical tube 24 which forms a closed sealed chamber which can form ahermetic seal around the specimen. Tube 24 is open at one end 26adjacent the specimen's head to receive threaded shaft 27 and open atits opposite or rear end 28. Tube end 26 is hermetically sealed byO-rings on shaft 27 when threaded end cap or nut 25 is torqued down onshaft 27. The O-rings form a seal with an internal cylindrical collarextending inwardly from the end wall 26. The tube 24 can be formed ofthin transparent plastic so as to be low cost and potentially disposableafter one or more imaging procedures.

As seen in FIG. 2, a first hermetic seal 30 is formed between the animalholding system 12 and tube 24. Seal 30 is formed by one or more o-rings32 seated in annular circumferential grooves 34 (FIG. 3) provided in anannular wall 36 at a rear end portion of the animal holding system 12.In the example shown, wall 36 can be an outer portion of theinterconnection panel 18. Hermetic seal 30 is formed by a simple axialsliding friction fit between the inner wall 40 (FIG. 2) of tube 24 andthe o-rings 32, which are compressed within grooves 34 and against wall40.

In order to accommodate a remote catheter which communicates with theinterior of tube 24 and with the external ambient environment, a secondhermetic seal assembly 50 (FIGS. 2 and 3) is provided along, over andbetween the first seal 30 and the tube 24. The second seal assembly 50includes a soft, easily axially and radially resilient, compressible,elastomeric plug 54 provided on or over a catheter tube 56. The cathetertube 56 can include a needle 60 at one axial end portion for insertioninto a specimen, such as within the tail vein of a laboratory mouseimmobilized on the animal bed 14, as shown in FIG. 1. A hypodermicneedle or drip tube can be used to introduce material into the otheraxial end of the tube 56 such as through a fluid fitting 58.

The second seal assembly 50 also includes a recess or pocket 64 (FIG. 1)provided on the rear end 28 of tube 24. Pocket 64 can be formed tocompliment, match and compress the outer contours of the plug 54. Thatis, pocket 64 and plug 54 are dimensioned to form a compressiveinterference fit that forces the plug 54 radially inwardly against theo-rings 32. and against wall 36 to fowl the second hermetic sealassembly 50. At the same time, the plug 54 is compressed against theinner walls of pocket 64 to complete the seal assembly 50 as tube 24 isaxially moved over wall 36 and radially compresses the 0-rings 32.

The axial length of pocket 64 is less than the axial length of the plug54 so that when the tube 24 is fully axially seated against the radialwall 70, the axially-tapered inner wall 72 of pocket 64 axially pushesthe outer tapered wall 74 of plug 54 toward radial wall 70 to form asealing interface between the rear wall 98 (FIG. 5) of plug 54 and theradial wall 70.

As seen in FIGS. 4, 5 and 6, plug 54 can be overmolded or assembled onan outer wall of the catheter tube 56. A locating sleeve 80 can beintegrally formed with the plug 54 to fit within a positioning slot 82(FIG. 1) on the rear end of the animal alignment system 12, such aswithin a slot in the radial wall 70 and in wall 36. A radically enlargedannular flange 84 is located at one end of a radially reduced orradially necked-down sleeve 80 and a radially enlarged portion of plug54 is located at the other end of sleeve 80. The axial length of sleeve80 is about the same as the axial length of the positioning slot 82.This dimensioning axially and circumferentially positions the plug 54 onthe walls 36 and 70.

In the example shown in the drawings, the plug 54 has a contoured orconcave radially inner bottom wall 90 (FIG. 6) which matches orcompliments the cylindrical surface of the radial wall 36 against whichit forms a seal, and an arched radially outer upper portion 92 boundedby a planar radial front wall 96 and a planar radial rear wall 98. Dueto the axial taper of plug 54, the front wall 96 is smaller than therear wall 98.

The upper portion 92 and bottom or radially inner wall 90 taperoutwardly (circumferentially) from the smaller front wall 96 to thelarger rear wall 98.

With the seal 50 as described above, a simple, inexpensive anddisposable catheter and seal assembly 100 (FIG. 4) is provided forsimple and effective treatment of laboratory animals held within ananimal holding system 12.

1. A catheter and seal assembly comprising: a catheter tube having anaxis, and a seal provided on said catheter tube, said seal having anaxially and radially compressible plug portion, said plug portion havinga radially-extending sealing wall and an axially-extending and axiallytapering sealing wall.
 2. The assembly of claim 1, further comprising aradially necked down sleeve and a radially enlarged flange coupled tosaid catheter.
 3. The assembly of claim 2, wherein said plug portioncomprises a concave radially inner wall portion and an arched radiallyouter wall portion.
 4. The assembly of claim 1, wherein said plugportion further comprises a radially-extending front wall and whereinsaid front wall is axially spaced from said sealing wall and whereinsaid front wall is smaller than said sealing wall.
 5. The assembly ofclaim 4, wherein said front wall and said sealing wall each comprisesradially-extending planar walls. 6-12. (canceled)
 13. A catheter andseal assembly, comprising: a catheter tube having an axis and a firstend and a second end; a needle provided on said first end of saidcatheter tube; and an axially and radially compressible elastomeric plugprovided on said catheter tube and configured to form a seal.
 14. Thecatheter and seal assembly of claim 13, further comprising a fluidfitting provided on said second end of said catheter tube.
 15. Thecatheter and seal assembly of claim 13, further comprising a locatingsleeve provided on said catheter tube adjacent to said plug.
 16. Thecatheter and seal assembly of claim 13, further comprising an annularflange provided on said catheter tube adjacent to said plug.
 17. Thecatheter and seal assembly of claim 13, wherein said plug comprises aconcave bottom wall.
 18. The catheter and seal assembly of claim 13,wherein said plug comprises an axially tapered plug.
 19. The catheterand seal assembly of claim 13, wherein said plug comprises an archedupper portion.
 20. The catheter and seal assembly of claim 13, whereinsaid plug comprises a planar front radial wall and a planar rear radialwall.
 21. The catheter and seal assembly of claim 20, wherein said frontwall is smaller than said rear wall.